| Carlos Holguín Sardi | |
| Office: | Minister of the Interior and Justice |
| President: | Álvaro Uribe |
| Predecessor: | Sabas Pretelt de la Vega |
| Successor: | Fabio Valencia Cossio |
| Office2: | Senator of Colombia |
| Order4: | 64th |
| Office4: | Governor of Valle del Cauca |
| Predecessor4: | Luis Fernando Cruz Gómez |
| Successor4: | Germán Villegas Villegas |
| Office5: | President of the Senate |
| Predecessor5: | Bernardo Guerra Serna |
| Successor5: | José Name Terán |
| Order6: | 54th |
| Office6: | Governor of Valle del Cauca |
| President6: | Alfonso López Michelsen |
| Predecessor6: | Raúl Orejuela Bueno |
| Successor6: | Jaime Arizabaleta Calderón |
| Office7: | Minister of Communications |
| President7: | Misael Pastrana Borrero |
| Predecessor7: | Juan Bautista Fernandez |
| Successor7: | Jaime Garcia Parra |
| Office8: | Mayor of Santiago de Cali |
| Term Start8: | September 1970 |
| Predecessor8: | José Vicente Borrero |
| Successor8: | Alfredo Carvajal |
| Office9: | Member of the Chamber of Representatives |
| Birth Name: | Carlos Holguín Sardi |
| Constituency9: | Cuaca Valley |
| Birth Date: | 16 September 1940 |
| Birth Place: | Cali, Cauca Valley, Colombia |
| Nationality: | Colombian |
| Party: | Conservative |
| Alma Mater: | Pontifical Xavierian University |
| Profession: | Lawyer |
Carlos Holguín Sardi (born 16 December 1940) was the 64th and 54th Governor of Valle del Cauca. A Conservative party politician, he served as the 3rd Minister of the Interior and Justice of Colombia from 2006 to 2008, and as the 20th Minister of Communications of Colombia from 1973 to 1974.
When he was just 25, he was elected to the Chamber of Representatives of Colombia for Valle del Cauca and served from 1966 to 1970. He was elected again to Congress in 1982 as Senator of Colombia and served from 1982 to 1990, and again from 1998 to 2006.