| Carlisle High School | |
| Streetaddress: | 250 Jamaica Road |
| Zipcode: | 45005 |
| Country: | USA |
| Coordinates: | 39.5881°N -84.3228°W |
| District: | Carlisle Local Schools |
| Superintendent: | David Vail |
| Principal: | Andrew Huber |
| Teaching Staff: | 24.00 (FTE) |
| Ratio: | 18.79 |
| Nickname: | Indians |
| Enrollment: | 451 (2019-2020) |
Carlisle High School is a public high school in Carlisle, Ohio and is a part of the Carlisle Local Schools.
The school was originally located in a two story building on the corner of Jamaica Road and Fairview Drive. It is now at 250 Jamaica Road.