| Official Name: | Carlisle, Mississippi |
| Pushpin Map: | Mississippi#USA |
| Pushpin Label: | Carlisle |
| Pushpin Label Position: | bottom |
| Subdivision Type: | Country |
| Subdivision Name: |  United States |
| Subdivision Type1: | State |
| Subdivision Type2: | County |
| Subdivision Name2: | Claiborne |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Ft: | 121 |
| Coordinates: | 32.0028°N -90.7844°W |
| Postal Code Type: | ZIP code |
| Area Code: | 601 & 769 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 691750 |
Carlisle is an unincorporated community in Claiborne County, Mississippi, United States.
The Bayou Pierre, a tributary to the Mississippi River, flows north of the community.
Carlisle is located on the former Natchez, Jackson and Columbus Railroad, completed in 1882. Known locally as "The Little J", the line ran between Jackson and Natchez, and had various owners, including the Illinois Central Railroad, which abandoned it between 1979 and 1981.[1] [2]
Carlisle was once home to a cotton gin and school.[3] Two general stores were also located in Carlisle.[4]
A post office first began operation under the name Carlisle in 1884.[5]
Carlisle is served by the Claiborne County School District.