Carl-Philipp Heisenberg Explained

Carl-Philipp Heisenberg (born 1968) is a German developmental biologist specializing in embryology, cell biology, and biophysics. He is the grandson of the physicist Werner Heisenberg and nephew of biologist Martin Heisenberg. He was born in Munich, Germany.

After graduating in Biology in Munich in 1992, he carried out his PhD work with Christiane Nüsslein-Volhard in Tübingen in 1997.[1] After a postdoc with Stephen Wilson at University College London,[2] he started his research group in 2001 at the Max Planck Institute for Cell Biology and Genetics in Dresden as an Emmy Noether junior professor.[3] Since 2010, he is a professor at the Institute of Science and Technology Austria.[4]

Heisenberg was elected member of the German National Academy of Sciences Leopoldina in 2015[5] and of the European Molecular Biology Organisation in 2016.[6] In 2019, he received the Carus medal from the Leopoldina.[7]

Heisenberg's research focuses on characterising the molecular, cellular and physical regulation of embryonic development.[4] Using mostly zebrafish as a model organism, his group has identified how cytoskeletal and adhesive elements control the physical properties of tissues during gastrulation.[8] [9] [10] [11] [12] [13] [14] [15]

Notes and References

  1. Heisenberg . C.P. . Brand . M. . Jiang . Y.J. . Warga . R.M. . Beuchle . D. . van Eeden . F.J. . Furutani-Seiki . M. . Granato . M. . Haffter . P. . Hammerschmidt . M. . Kane . D.A. . Kelsh . R.N. . Mullins . M.C. . Odenthal . J. . Nusslein-Volhard . C. . Genes involved in forebrain development in the zebrafish, Danio rerio . Development . 1 December 1996 . 123 . 1 . 191–203 . 10.1242/dev.123.1.191 . 9007240 .
  2. Heisenberg . Carl-Philipp . Tada . Masazumi . Rauch . Gerd-Jörg . Saúde . Leonor . Concha . Miguel L. . Geisler . Robert . Stemple . Derek L. . Smith . James C. . Wilson . Stephen W. . Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation . Nature . May 2000 . 405 . 6782 . 76–81 . 10.1038/35011068 . 10811221 . 2000Natur.405...76H . 4397286 .
  3. Web site: MPI-CBG: Alumni. www.mpi-cbg.de.
  4. Web site: Heisenberg Group.
  5. Web site: Mitglieder. Nationale Akademie der Wissenschaften Leopoldina.
  6. Web site: Find people in the EMBO Communities. people.embo.org.
  7. Web site: Carus Medal awarded to IST Austria professor Carl-Philipp Heisenberg.
  8. Krieg . M. . Arboleda-Estudillo . Y. . Puech . P.-H. . Käfer . J. . Graner . F. . Müller . D. J. . Heisenberg . C.-P. . Tensile forces govern germ-layer organization in zebrafish . Nature Cell Biology . April 2008 . 10 . 4 . 429–436 . 10.1038/ncb1705 . 18364700 . 22340931 .
  9. Maitre . J.-L. . Berthoumieux . H. . Krens . S. F. G. . Salbreux . G. . Julicher . F. . Paluch . E. . Heisenberg . C.-P. . Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells . Science . 12 October 2012 . 338 . 6104 . 253–256 . 10.1126/science.1225399 . 22923438 . 2012Sci...338..253M . 7330288 .
  10. Behrndt . M. . Salbreux . G. . Campinho . P. . Hauschild . R. . Oswald . F. . Roensch . J. . Grill . S. W. . Heisenberg . C.-P. . Forces Driving Epithelial Spreading in Zebrafish Gastrulation . Science . 12 October 2012 . 338 . 6104 . 257–260 . 10.1126/science.1224143 . 23066079 . 2012Sci...338..257B . 34962468 .
  11. Ruprecht . Verena . Wieser . Stefan . Callan-Jones . Andrew . Smutny . Michael . Morita . Hitoshi . Sako . Keisuke . Barone . Vanessa . Ritsch-Marte . Monika . Sixt . Michael . Voituriez . Raphaël . Heisenberg . Carl-Philipp . Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility . Cell . February 2015 . 160 . 4 . 673–685 . 10.1016/j.cell.2015.01.008 . 25679761 . 4328143 .
  12. Schwayer . Cornelia . Shamipour . Shayan . Pranjic-Ferscha . Kornelija . Schauer . Alexandra . Balda . Maria . Tada . Masazumi . Matter . Karl . Heisenberg . Carl-Philipp . Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow . Cell . October 2019 . 179 . 4 . 937–952.e18 . 10.1016/j.cell.2019.10.006 . 31675500 . 204972165 .
  13. Petridou . Nicoletta I. . Corominas-Murtra . Bernat . Heisenberg . Carl-Philipp . Hannezo . Edouard . Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions . Cell . April 2021 . 184 . 7 . 1914–1928.e19 . 10.1016/j.cell.2021.02.017 . 33730596 . 8055543 .
  14. Shamipour . Shayan . Kardos . Roland . Xue . Shi-Lei . Hof . Björn . Hannezo . Edouard . Heisenberg . Carl-Philipp . Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes . Cell . May 2019 . 177 . 6 . 1463–1479.e18 . 10.1016/j.cell.2019.04.030 . 31080065 . free .
  15. Xia . Peng . Gütl . Daniel . Zheden . Vanessa . Heisenberg . Carl-Philipp . Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity . Cell . March 2019 . 176 . 6 . 1379–1392.e14 . 10.1016/j.cell.2019.01.019 . 30773315 . free .

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