Pope Pius VI (r. 1775–1799) created 73 cardinals in 23 consistories.
| Name | Title when named cardinal |
|---|---|
| 1. Bernardino Honorati (b. 1724) | |
| 2. Marcantonio Marcolini (b. 1721) | |
| 3. Guglielmo Pallotta (b. 1727) | |
| 4. Gregorio Salviati (b. 1722) | |
| 5. Andrea Gioannetti (b. 1722) | |
| 6. Hyacinthe Sigismond Gerdil (b. 1718) | |
| 7. Giovanni Ottavio Manciforte Sperelli (b. 1730) | |
| 8. Vincenzo Maria Altieri (b. 1724) | |
| Name | Title when named cardinal |
|---|---|
| 1. Francisco Javier Delgado y Venegas (b. 1714) | Archbishop of Seville, Spain |
| 2. Dominique de La Rochefoucauld (b. 1712) | Archbishop of Rouen, France |
| 3. Joannes-Henricus de Franckenberg (b. 1726) | Archbishop of Mechelen, Austrian Netherlands |
| 4. József Batthyány (b. 1727) | Archbishop of Esztergom, Hungary |
| 5. Tommaso Maria Ghilini (b. 1718) | Titular Archbishop of Rhodes, Greece |
| 6. Carlo Giuseppe Filippa della Martiniana (b. 1724) | Bishop of Maurienne, France |
| 7. Louis-René-Édouard de Rohan-Guéménée (b. 1734) | |
| 8. Fernando de Sousa e Silva (b. 1712) | |
| 9. Giovanni Cornaro (b. 1720) | |
| 10. Romoaldo Guidi (b. 1722) | |