Carbromal Explained

Carbromal is a hypnotic/sedative originally synthesized in 1909 by Bayer and subsequently marketed as Adalin.[1] [2] The drug was later sold by Parke-Davis in combination with pentobarbital, under the name Carbrital.[3]

Synthesis

Diethylmalonic acid [510-20-3] (1) is decarboxylated to 2-ethylvaleric acid [20225-24-5] (2). The Hell-Volhard-Zelinsky reaction converts this to 2-Bromo-2-Ethylbutyryl Bromide [26074-53-3] (3). Reaction with urea with affords carbromal (4).

See also

Notes and References

  1. Borrie P . A purpuric drug eruption caused by carbromal . British Medical Journal . 1 . 4914 . 645–6 . March 1955 . 13230580 . 2061381 . 10.1136/bmj.1.4914.645 .
  2. DE. 22571. 1910-09-17. Verfahren dur Darstellung von Bromodiäthylacetylharnstoff [Method for the preparation of bromodiethylacetylurea]. Friedrich Bayer & Co..
  3. Book: Physicians' Desk Reference.. 1979. Medical Economics Co. 0-87489-999-0. 33. Oradell, N.J.. 1266. 4636066.

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