Carboxypeptidase U Explained

Carboxypeptidase U
Ec Number:	3.4.17.20
Cas Number:	156621-18-0

Carboxypeptidase U (arginine carboxypeptidase, carboxypeptidase R, plasma carboxypeptidase B, thrombin-activatable fibrinolysis inhibitor) is an enzyme.^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

Release of C-terminal Arg and Lys from a polypeptide

Pro-carboxypeptidase U in (human) plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.

See also

• Carboxypeptidase

Notes and References

1. Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D . Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma . The Journal of Biological Chemistry . 266 . 32 . 21833–8 . November 1991 . 1939207 .
2. Shinohara T, Sakurada C, Suzuki T, Takeuchi O, Campbell W, Ikeda S, Okada N, Okada H . Pro-carboxypeptidase R cleaves bradykinin following activation . International Archives of Allergy and Immunology . 103 . 4 . 400–4 . 1994 . 8130654 . 10.1159/000236661 .
3. Wang W, Hendriks DF, Scharpé SS . Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen . The Journal of Biological Chemistry . 269 . 22 . 15937–44 . June 1994 . 8195249 .
4. Tan AK, Eaton DL . Activation and characterization of procarboxypeptidase B from human plasma . Biochemistry . 34 . 17 . 5811–6 . May 1995 . 7727441 . 10.1021/bi00017a012 .
5. Broze GJ, Higuchi DA . Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma . Blood . 88 . 10 . 3815–23 . November 1996 . 8916945 .