Carboxypeptidase A1 Explained

Carboxypeptidase A1 is an enzyme that in humans is encoded by the CPA1 gene.^[1]

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. Carboxypeptidase A1 is a monomeric pancreatic exopeptidase. It is involved in zymogen inhibition.^[2]

Further reading

• Catasús L, Villegas V, Pascual R . cDNA cloning and sequence analysis of human pancreatic procarboxypeptidase A1. . Biochem. J. . 287 . 1. 299–303 . 1992 . 1417781 . 1133158 . 10.1042/bj2870299. etal.
• Stewart EA, Craik CS, Hake L, Bowcock AM . Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter. . Am. J. Hum. Genet. . 46 . 4 . 795–800 . 1990 . 1969228 . 1683655 .
• Moulard M, Michon T, Kerfelec B, Chapus C . Further studies on the human pancreatic binary complexes involving procarboxypeptidase A. . FEBS Lett. . 261 . 1 . 179–83 . 1990 . 2307232 . 10.1016/0014-5793(90)80665-6 . 6705621 . free .
• Pascual R, Burgos FJ, Salva M . Purification and properties of five different forms of human procarboxypeptidases. . Eur. J. Biochem. . 179 . 3 . 609–16 . 1989 . 2920728 . 10.1111/j.1432-1033.1989.tb14590.x . etal. free .
• Honey NK, Sakaguchi AY, Lalley PA . Assignment of the gene for carboxypeptidase A to human chromosome 7q22----qter and to mouse chromosome 6. . Hum. Genet. . 72 . 1 . 27–31 . 1986 . 3455919 . 10.1007/BF00278813 . 38300147 . etal.
• Velculescu VE, Zhang L, Vogelstein B, Kinzler KW . Serial analysis of gene expression. . Science . 270 . 5235 . 484–7 . 1995 . 7570003 . 10.1126/science.270.5235.484 . 1995Sci...270..484V . 16281846 .
• Laethem RM, Blumenkopf TA, Cory M . Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. . Arch. Biochem. Biophys. . 332 . 1 . 8–18 . 1996 . 8806703 . 10.1006/abbi.1996.0310 . etal.
• Bonora E, Bacchelli E, Levy ER . Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. . Mol. Psychiatry . 7 . 3 . 289–301 . 2002 . 11920156 . 10.1038/sj.mp.4001004 . etal. 13282515 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• Scherer SW, Cheung J, MacDonald JR . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 . etal.

External links

• The MEROPS online database for peptidases and their inhibitors: M14.001

Notes and References

1. Web site: Entrez Gene: CPA1 carboxypeptidase A1 (pancreatic).
2. Web site: Entrez Gene: CPA1 carboxypeptidase A1 (pancreatic).