Carboxybiotin decarboxylase explained

Carboxybiotin decarboxylase
Ec Number:	7.2.4.1

Carboxybiotin decarboxylase (MadB, carboxybiotin protein decarboxylase) is an enzyme with systematic name carboxybiotinyl-(protein) carboxy-lyase.^{[1] [2]} This enzyme catalyses the following chemical reaction

a carboxybiotinyl-[protein] + n Na⁺_in + H⁺_out

\rightleftharpoons CO₂ + a biotinyl-[protein] + n Na⁺_out (n = 1--2)

This enzyme is an integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra.

Nomenclature

This enzyme was previously classified as .

Notes and References

1. Berg M, Hilbi H, Dimroth P . Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function . European Journal of Biochemistry . 245 . 1 . 103–15 . April 1997 . 9128730 . 10.1111/j.1432-1033.1997.00103.x . free .
2. Dimroth P, Hilbi H . Enzymic and genetic basis for bacterial growth on malonate . Molecular Microbiology . 25 . 1 . 3–10 . July 1997 . 11902724 . 10.1046/j.1365-2958.1997.4611824.x . free .