| Cassine | |
| Official Name: | Comune di Cassine |
| Coordinates: | 44.75°N 40°W |
| Region: | Piedmont |
| Province: | Alessandria (AL) |
| Frazioni: | Caranzano, Gavonata, Sant'Andrea |
| Area Total Km2: | 33.09 |
| Population Footnotes: | [1] |
| Population Total: | 2932 |
| Population As Of: | 31 August 2017 |
| Population Demonym: | Cassinesi |
| Elevation M: | 190 |
| Saint: | St. James |
| Day: | July 25 |
| Postal Code: | 15016 |
| Area Code: | 0144 |
Cassine (Piedmontese: Cassèine) is a town and commune of the Province of Alessandria in the Italian region Piedmont. It is located 21km (13miles) southwest of the town of Alessandria on the left of the lower course of the Bormida in the Alto Monferrato Acquese. The town lies partly in the hills, where the ancient nucleus of the settlement formed, and partly on the plain. Its economic character is agricultural: the hills are rich in vineyards where the wines Moscato d'Asti, Barbera and Freisa are produced as well as grappa.
In addition to the nucleus of Cassine itself (the capoluogo) three frazioni fall within the boundaries of the commune: Caranzano, Gavonata, and Sant'Andrea.
Cassine borders the following communes: Alice Bel Colle, Castelnuovo Bormida, Gamalero, Maranzana, Mombaruzzo, Ricaldone, Rivalta Bormida, Sezzadio, and Strevi.
During the 10th century the town was within the domains of the Bishops of Acqui. In 1164, Emperor Frederick I Barbarossa granted it to the Marquis of Montferrat. However, located at the edge of the Ghibelline marquisate, control of Cassine was contested by the Guelfs of Alessandria who conquered and destroyed the town in 1231 and subsequently exacted an annual tribute. In 1404 it was occupied by the condottiere Facino Cane. Subsequently it was fortified. In 1451 the town was besieged by the Marquis of Montferrat. It was occupied by Charles V, Holy Roman Emperor in 1556, and in 1644 it was taken control of by the French. In 1707 Cassine was annexed to the Kingdom of Sardinia and from that time on its fortunes followed those of other towns in Piedmont.