Cannflavin Explained

Cannflavins are a group of chemical compounds found in Cannabis sativa.[1] Chemically, they are prenylflavonoids and are unrelated to THC and other cannabinoids. Cannflavins A and B were first identified in the 1980s and cannflavin C was identified in 2008.[2]

Because cannflavins A and B are inhibitors of prostaglandin E2 production in vitro,[1] [3] the cannflavins have been studied for their potential use as anti-inflammatory agents.

Biosynthesis

Cannflavins A and B are biosynthesized by prenylation of chrysoeriol.

Notes and References

  1. 10.1007/BF02118655 . 3754224 . Cannflavin A and B, prenylated flavones from Cannabis sativa L . Experientia . 42 . 4 . 452–453 . 1986 . Barrett . M. L. . Scutt . A. M. . Evans . F. J. . 19652191 .
  2. 10.1016/j.phytochem.2008.07.010 . 18774146 . 4888767 . Non-cannabinoid constituents from a high potency Cannabis sativa variety . Phytochemistry . 69 . 14 . 2627–2633 . 2008 . Radwan . Mohamed M. . Elsohly . Mahmoud A. . Slade . Desmond . Ahmed . Safwat A. . Wilson . Lisa . El-Alfy . Abir T. . Khan . Ikhlas A. . Ross . Samir A. .
  3. 10.1016/0006-2952(85)90325-9 . 3859295 . Isolation from cannabis sativa L. Of cannflavin—a novel inhibitor of prostaglandin production . Biochemical Pharmacology . 34 . 11 . 2019–2024 . 1985 . Barrett . M.L. . Gordon . D. . Evans . F.J. .

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