Cannabipiperidiethanone Explained

Cannabipiperidiethanone (CPE or 1-(N-methylpiperidin-2-ylmethyl)-3-(2-methoxyphenylacetyl)indole) is a synthetic cannabinoid that has been found as an ingredient of "herbal" synthetic cannabis blends sold in Japan, alongside JWH-122 and JWH-081.

Its binding affinity was measured at the CB₁ and CB₂ receptors and it was found to have an IC₅₀ of 591 nM at CB₁ and 968 nM at CB₂, making it 2.3 times and 9.4 times weaker than JWH-250 at these two targets respectively.^[1]

In the United States, CB₁ receptor agonists of the 3-phenylacetylindole class such as cannabipiperidiethanone are Schedule I Controlled Substances.

See also

• AM-1220
• AM-1248
• AM-2233
• JWH-203
• RCS-8

References

1. Uchiyama N, Kikura-Hanajiri R, Goda Y . Identification of a novel cannabimimetic phenylacetylindole, cannabipiperidiethanone, as a designer drug in a herbal product and its affinity for cannabinoid CB₁ and CB₂ receptors . Chemical & Pharmaceutical Bulletin . 59 . 9 . 1203–5 . 2011 . 21881274 . 10.1248/cpb.59.1203. free .