Cannabidiorcol Explained

Cannabidiorcol (CBDO, CBD-C1, O-1821) is a phytocannabinoid found naturally in Cannabis in trace concentrations. It is related to cannabidiol, with the pentyl side chain shortened to a methyl group. Cannabidiorcol has low affinity for cannabinoid receptors and is mainly active as an agonist of the TRPV2 cation channel, through which it produces antiinflammatory effects,^[1] but can also promote tumorigenesis at high concentrations.^[2]

See also

• Abnormal cannabidiol
• Cannabidivarin
• O-1918
• Tetrahydrocannabiorcol

Notes and References

1. Laragione T, Harris C, Gulko PS . Combination therapy of a TRPV2 agonist with a TNF inhibitor achieves sustained suppression of disease severity and reduced joint damage . Clinical and Experimental Immunology . 211 . 3 . 233–238 . March 2023 . 36571199 . 10038320 . 10.1093/cei/uxac124 .
2. Huang R, Li S, Tian C, Zhou P, Zhao H, Xie W, Xiao J, Wang L, Habimana JD, Lin Z, Yang Y, Cheng N, Li Z . 6 . Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma . British Journal of Cancer . 127 . 8 . 1424–1439 . November 2022 . 35896815 . 10.1038/s41416-022-01896-2 . 9553907 .