Cannabidiol dimethyl ether explained

Cannabidiol dimethyl ether (CBDD) is a trace component of cannabis which can also be made synthetically. It is a potent and selective inhibitor of the enzyme 15-lipoxygenase and inhibits oxygenation of linoleic acid, a process involved in the development of atherosclerosis.^{[1] [2]}

See also

• 4'-Fluorocannabidiol
• 7-Hydroxycannabidiol
• 8,9-Dihydrocannabidiol
• Cannabicitran
• Cannabidiol diacetate
• Delta-6-Cannabidiol
• KLS-13019
• O-1918

Notes and References

1. Takeda S, Usami N, Yamamoto I, Watanabe K . Cannabidiol-2',6'-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor . Drug Metabolism and Disposition . 37 . 8 . 1733–7 . August 2009 . 19406952 . 10.1124/dmd.109.026930 . 1546599 .
2. Takeda S, Hirayama A, Urata S, Mano N, Fukagawa K, Imamura M, Irii A, Kitajima S, Masuyama T, Nomiyama M, Tatei S, Tomita S, Kudo T, Noguchi M, Yamaguchi Y, Okamoto Y, Amamoto T, Fukunishi Y, Watanabe K, Omiecinski CJ, Aramaki H . 6 . Cannabidiol-2',6'-dimethyl ether as an effective protector of 15-lipoxygenase-mediated low-density lipoprotein oxidation in vitro . Biological & Pharmaceutical Bulletin . 2011 . 34 . 8 . 1252–6 . 21804214 . 10.1248/bpb.34.1252 . 4012644 . free .