The Cancer Prevention Study (frequently abbreviated CPS) is the name of a series of cohort studies conducted in the United States by the American Cancer Society.
The first Cancer Prevention Study, known as CPS-I, recruited subjects between October 1959 and February 1960. This study included more than 1 million men and women.[1] The participants were followed until 1972.[2] The study showed that the increase in lung cancer mortality rates in women during the study's time period occurred only in smoking women.[2] It has been described as "a key guide to national policy and changing public attitudes" with regard to the link between cigarette smoking and lung cancer.[3]
The second Cancer Prevention Study, known as Cancer Prevention Study II or CPS-II, is a prospective study involving about 1.2 million American men and women, recruited by 77,000 American Cancer Society volunteers.[4] It began in 1982 under the direction of Lawrence Garfinkel.[5] Subjects examined in this study include putative cancer risk factors such as obesity and diet.[3]
The third Cancer Prevention Study, known as CPS-3, began enrollment in 2006[2] and completed recruitment in December 2013. The study includes over 304,000 participants.[6]