Canbisol Explained

Canbisol (Nabidrox), is a synthetic cannabinoid derivative that is the dimethylheptyl homologue of 9-nor-9β-hydroxyhexahydrocannabinol (HHC). It is a potent agonist at both the CB₁ and CB₂ receptors, with a binding affinity of 0.1 nM at CB₁ and 0.2 nM at CB₂.^[1] It is mainly used in scientific research, in receptor binding studies to determine the structure and function of the cannabinoid receptors,^{[2] [3] [4]} but has been made illegal in some countries due to its possible abuse potential as a cannabinomimetic drug.^[5]

See also

• CP 42,096
• HU-210
• HU-243
• Nabilone

Notes and References

1. Rhee MH, Vogel Z, Barg J, Bayewitch M, Levy R, Hanus L, Breuer A, Mechoulam R . 6 . Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase . Journal of Medicinal Chemistry . 40 . 20 . 3228–33 . September 1997 . 9379442 . 10.1021/jm970126f .
2. Rhee MH, Nevo I, Bayewitch ML, Zagoory O, Vogel Z . Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor . Journal of Neurochemistry . 75 . 6 . 2485–91 . December 2000 . 11080201 . 10.1046/j.1471-4159.2000.0752485.x . 18339666 .
3. Rhee MH . Functional role of serine residues of transmembrane dopamin VII in signal transduction of CB2 cannabinoid receptor . Journal of Veterinary Science . 3 . 3 . 185–91 . September 2002 . 12514330 . 10.4142/jvs.2002.3.3.185. free .
4. Zhang R, Hurst DP, Barnett-Norris J, Reggio PH, Song ZH . Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template . Molecular Pharmacology . 68 . 1 . 69–83 . July 2005 . 15840841 . 10.1124/mol.104.007823 . 6488891 .
5. http://www.opsi.gov.uk/si/si2009/draft/ukdsi_9780111486610_en_1 The Misuse of Drugs Act 1971 (Amendment) Order 2009