| Canale Reale | |
| Source1 Location: | near Francavilla Fontana |
| Mouth: | Adriatic Sea |
| Mouth Location: | near the Strait of Otranto |
| Mouth Coordinates: | 40.7048°N 17.8069°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Italy |
Canale Reale is an Italian river in the province of Brindisi.[1] The source of the river is near Francavilla Fontana. The river flows east for a distance before curving northeast near Latiano. It enters the Adriatic Sea near the Strait of Otranto between Villanova and Brindisi.