Calyculin Explained

Calyculins are natural products originally isolated from the marine sponge Discodermia calyx.[1] Calyculins have proven to be strong serine/threonine protein phosphatase inhibitors and based on this property, calyculins might be potential tumor-promoting agents.

A laboratory synthesis of calyculin A has been reported.[2]

Biosynthesis

Calyculin A is biosynthesized as a pyrophosphate containing phosphocalyculin A protoxins by a hybrid PKS-NRPS pathway within the sponge bacterial symbiont, "Candidatus Entotheonella" sp.[3]

Notes and References

  1. Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin. Suganuma M, Fujiki H, Furuya-Suguri H, Yoshizawa S, Yasumoto S, Kato Y, Fusetani N, Sugimura T. Cancer Res.. 1990. 50. 12. 3521–3525. 2160320.
  2. Tanimoto . Norihiko . Gerritz . Samuel W. . Sawabe . Akiyoshi . Noda . Takeshi . Filla . Sandra A. . Masamune . Satoru . 1994-03-17 . Synthese von natürlich vorkommendem (−)‐Calyculin A . Angewandte Chemie . en . 106 . 6 . 674–677 . 10.1002/ange.19941060611 . 0044-8249.
  3. Jomori . Takahiro . Matsuda . Kenichi . Egami . Yoko . Abe . Ikuro . Takai . Akira . Wakimoto . Toshiyuki . Insights into phosphatase-activated chemical defense in a marine sponge holobiont . RSC Chemical Biology . 2 . 6 . 2021 . 2633-0679 . 34977575 . 8637855 . 10.1039/D1CB00163A . free . 1600–1607.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Calyculin".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2025, A B Cryer, All Rights Reserved. Cookie policy.