Calycosin Explained

Calycosin is an O-methylated isoflavone. It can be isolated from Astragalus membranaceus Bge. var. mongholicus[1] and Trifolium pratense L. (red clover).[2]

Biosynthesis

Isoflavone 3′-hydroxylase uses formononetin, NADPH, H+ and O2 to produce calycosin, NADP+ and H2O.

Notes and References

  1. 10.1016/S0021-9673(02)00535-6. 12198969. Preparative isolation and purification of calycosin from Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao by high-speed counter-current chromatography. Journal of Chromatography A. 962. 1–2. 243–7. 2002. Ma. Xiaofeng. Zhang. Tianyou. Wei. Yun. Tu. Pengfei. Chen. Yingjie. Ito. Yoichiro.
  2. 10.1016/S0031-9422(00)94679-X. Identification of isoflavones calycosin and pseudobaptigenin in Trifolium pratense. Phytochemistry. 17. 9. 1683. 1978. Biggs. David R. Lane. Geoffrey A. 1978PChem..17.1683B.

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