Calponin family repeat explained

Symbol:	Calponin
Calponin
Pfam:	PF00402
Interpro:	IPR000557
Prosite:	PDOC00808

In molecular biology, the calponin family repeat is a 26 amino acid protein domain. Calponin 1 (CNN1) contains three copies of this domain. This domain is also found in vertebrate smooth muscle protein (SM22 or transgelin), and a number of other proteins whose physiological role is not yet established, including Drosophila synchronous flight muscle protein SM20, Caenorhabditis elegans unc-87 protein,^[1] rat neuronal protein NP25,^[2] and an Onchocerca volvulus antigen.^[3]

Notes and References

1. Goetinck S, Waterston RH . The Caenorhabditis elegans muscle-affecting gene unc-87 encodes a novel thin filament-associated protein . J. Cell Biol. . 127 . 1 . 79–93 . October 1994 . 7929573 . 2120179 . 10.1083/jcb.127.1.79.
2. Ren WZ, Ng GY, Wang RX, Wu PH, O'Dowd BF, Osmond DH, George SR, Liew CC . The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations . Brain Res. Mol. Brain Res. . 22 . 1–4 . 173–85 . March 1994 . 8015377 . 10.1016/0169-328X(94)90045-0.
3. Irvine M, Huima T, Prince AM, Lustigman S . Identification and characterization of an Onchocerca volvulus cDNA clone encoding a highly immunogenic calponin-like protein . Mol. Biochem. Parasitol. . 65 . 1 . 135–46 . May 1994 . 7935620 . 10.1016/0166-6851(94)90122-8.