| State: | CA |
| Type: | SR |
| Route: | 281 |
| Map Custom: | yes |
| Map Notes: | SR 281 highlighted in red |
| Alternate Name: | Soda Bay Road |
| Section: | 581 |
| Length Mi: | 3.000 |
| Length Notes: | Length of unconstructed portion is about 14 mi (22 km) |
| Direction A: | West |
| Terminus A: | Soda Bay Road at Clear Lake |
| Direction B: | East |
| Terminus B: | near Glenview |
| Counties: | Lake |
| Previous Type: | I |
| Previous Route: | 280 |
| Next Type: | SR |
| Next Route: | 282 |
State Route 281 (SR 281) is an approximately 3miles state highway in the U.S. state of California that runs along Soda Bay Road from near the southern shore of Clear Lake to State Route 29 (SR 29) in Glenview in Lake County. SR 281 is legislatively defined to be a loop route of SR 29 that runs along or near the southern edge of Clear Lake from Glenview to Lakeport, but most of this is unconstructed.
The route currently begins at Clear Lake from Soda Bay Road and heads south. After three miles, it meets its south end at State Route 29.
The planned segment west along Soda Bay Road to Lakeport remains unconstructed. This portion of Soda Bay Road is currently Lake County Route 502.
SR 281 is not part of the National Highway System, a network of highways that are considered essential to the country's economy, defense, and mobility by the Federal Highway Administration.