| Caleb Shaffner | |
| Birth Date: | 1 February 1846 |
| Nationality: | Canadian |
| Party: | Conservative Party of Nova Scotia |
| Birth Place: | Nicteaux, Annapolis County, Nova Scotia |
| Death Place: | Truro, Nova Scotia |
| Alma Mater: | Acadia College |
| Occupation: | Travelling salesman, politician, militia lieutenant-colonel |
| Office: | Member of the Nova Scotia House of Assembly for Annapolis |
| Predecessor: | Avard Longley |
| Successor: | James Wilberforce Longley |
Caleb Willoughby Shaffner (February 1, 1846 - December 28, 1904) was a travelling salesman and political figure in Nova Scotia, Canada. He represented Annapolis County in the Nova Scotia House of Assembly from 1878 to 1882 as a Conservative member.
He was born in Nicteaux, Annapolis County, Nova Scotia, of German descent, and was educated at Acadia College. In 1871, he married Annie Wood. He was a lieutenant-colonel in the local militia. Shaffner lived in Wilmot, Nova Scotia. He died in Truro at the age of 87.