| Cale James Holder | |
| Office: | Judge of the United States District Court for the Southern District of Indiana |
| Term Start: | August 6, 1954 |
| Term End: | August 23, 1983 |
| Appointer: | Dwight D. Eisenhower |
| Predecessor: | Seat established by 68 Stat. 8 |
| Successor: | Sarah Evans Barker |
| Birth Name: | Cale James Holder |
| Birth Date: | 5 April 1912 |
| Birth Place: | Lawrenceville, Illinois |
| Education: | Indiana University Robert H. McKinney School of Law (LL.B., J.D.) |
Cale James Holder (April 5, 1912 – August 23, 1983) was a United States district judge of the United States District Court for the Southern District of Indiana.
Born in Lawrenceville, Illinois, Holder received a Bachelor of Laws from Benjamin Harrison Law School (now Indiana University Robert H. McKinney School of Law) in 1934, and a Juris Doctor from Indiana Law School (also now Indiana University Robert H. McKinney School of Law) in 1938. He was in private practice in Indianapolis, Indiana from 1934 to 1954. He was a deputy prosecutor for the 19th Judicial Circuit, Marion County Criminal Court in Indiana from 1940 to 1942. He served as a lieutenant in the United States Navy during World War II, from 1942 to 1946. He was a special attorney of the Indiana State Personnel Board from 1946 to 1949, and was a deputy state attorney general of Indiana in 1953.
On August 2, 1954, Holder was nominated by President Dwight D. Eisenhower to a new seat on the United States District Court for the Southern District of Indiana created by 68 Stat. 8. He was confirmed by the United States Senate on August 6, 1954, and received his commission the same day. Holder served in that capacity until his death on August 23, 1983.