Calcium-binding mitochondrial carrier protein SCaMC-1 explained
Calcium-binding mitochondrial carrier protein SCaMC-1 is a protein that in humans is encoded by the SLC25A24 gene.[1]
Function
This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene.
Further reading
- Fiermonte G, De Leonardis F, Todisco S, Palmieri L, Lasorsa FM, Palmieri F . Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution . The Journal of Biological Chemistry . 279 . 29 . 30722–30 . July 2004 . 15123600 . 10.1074/jbc.M400445200 . free .
- del Arco A, Satrústegui J . Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains . The Journal of Biological Chemistry . 279 . 23 . 24701–13 . June 2004 . 15054102 . 10.1074/jbc.M401417200 . free .
- Traba J, Del Arco A, Duchen MR, Szabadkai G, Satrústegui J . SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering . Cell Death and Differentiation . 19 . 4 . 650–60 . April 2012 . 22015608 . 3307981 . 10.1038/cdd.2011.139 .
- Palmieri F . The mitochondrial transporter family SLC25: identification, properties and physiopathology . Molecular Aspects of Medicine . 34 . 2–3 . 465–84 . 2013 . 23266187 . 10.1016/j.mam.2012.05.005 .
- Jia L, Young MF, Powell J, Yang L, Ho NC, Hotchkiss R, Robey PG, Francomano CA . Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis . Genomics . 79 . 1 . 7–17 . January 2002 . 11827452 . 10.1006/geno.2001.6683 .
Notes and References
- Web site: Entrez Gene: Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 .
