Calcipressin Explained
| Symbol: | Calcipressin |
| Calcipressin |
| Pfam: | PF04847 |
| Pfam Clan: | CL0221 |
| Interpro: | IPR006931 |
In molecular biology, the calcipressin family of proteins negatively regulate calcineurin by direct binding. They are essential for the survival of T helper type 1 cells. Calcipressin 1 is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the conserved FLISPP motif; this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation.[1]
In humans, the Calcipressins family of proteins is derived from three genes:
- Calcipressin 1 (encoded by RCAN1) is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syndrome critical region 1 (DSCR1).
- Calcipressin 2 (encoded by RCAN2) is variously known as MCIP2, ZAKI-4 and DSCR1-like 1.
- Calcipressin 3 (encoded by RCAN3) is also called MCIP3 and DSCR1-like 2.[2]
Notes and References
- Genesca L, Aubareda A, Fuentes JJ, Estivill X, De La Luna S, Perez-Riba M . Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life . Biochem. J. . 374 . Pt 2 . 567–75 . September 2003 . 12809556 . 1223619 . 10.1042/BJ20030267 .
- Parry RV, June CH . Calcium-independent calcineurin regulation . Nat. Immunol. . 4 . 9 . 821–3 . September 2003 . 12942079 . 10.1038/ni0903-821 . 7858766 .
