| Caguán River | |
| Pushpin Map: | Colombia |
| Pushpin Map Caption: | Mouth location in Colombia |
| River System: | Caquetá River |
| Mouth Coordinates: | -0.1352°N -74.2888°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Colombia |
| Length: | 470[1] |
The Caguán River (Spanish; Castilian: Río Caguán, pronounced as /es/) is a river of Colombia. It is a tributary of the Caquetá River in the Amazon River basin.
It defines the eastern boundary of the Napo moist forests ecoregion.