| Cafundó River | |
| Source1 Location: | Alagoas state |
| Mouth Location: | Porto Real do Colégio |
| Mouth: | São Francisco River |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Cafundó River, also known as the Itiúba River, is a river of Alagoas state in eastern Brazil. It is a tributary of the São Francisco River.