| Cafayate | |
| Settlement Type: | Department |
| Mapsize: | 250px |
| Coordinates: | -26.0694°N -65.9761°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Area Footnotes: | [1] |
| Area Total Km2: | 1570 |
| Population Total: | 11785 |
| Population As Of: | 2010 |
| Population Density Km2: | auto |
Cafayate is a department located in Salta Province, in northwestern Argentina.
Situated in the south of the province and with an area of 1570sqkm it borders the departments of San Carlos, La Viña, Guachipas and the provinces of Tucumán and Catamarca.
The main rivers in the region are Calchaquí, and Santa María. Both end at the area called Las Juntas or La Ciénaga, joining at the beginning of the Las Conchas river, which runs in the same-named vallery to the northwest, ending at the Cabra Corral reservoir.
The Department is known for its vineyards. Cafayate has other tourist sites such as an 18th-century mill built by the Jesuits which is still used on occasion for the tourism trade.