CDH11 explained

Cadherin-11 is a protein that in humans is encoded by the CDH11 gene.^{[1] [2]}

Function

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. The mammalian CDH-11 homologues are termed calsyntenin.^[3]

Relevance to cancer

CDH11 is overexpressed in 15% of breast cancers and seems essential to tumour progression in some other cancer types.^{[4] [5]}

Drug interactions

Arthritis drug celecoxib binds to CDH11.^{[4] [5]}

Interactions

CDH11 has been shown to interact with CDH2.^[6]

References

Further reading

• Suzuki S, Sano K, Tanihara H . Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. . Cell Regul. . 2 . 4 . 261–70 . 1991 . 2059658 . 361775 . 10.1091/mbc.2.4.261 .
• Tanihara H, Sano K, Heimark RL, St John T, Suzuki S . Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. . Cell Adhes. Commun. . 2 . 1 . 15–26 . 1995 . 7982033 . 10.3109/15419069409014199 .
• Okazaki M, Takeshita S, Kawai S, Kikuno R, Tsujimura A, Kudo A, Amann E . Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. . J. Biol. Chem. . 269 . 16 . 12092–8 . 1994 . 10.1016/S0021-9258(17)32685-6 . 8163513 . free .
• Getsios S, Chen GT, Stephenson MD, Leclerc P, Blaschuk OW, MacCalman CD . Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium. . Dev. Dyn. . 211 . 3 . 238–47 . 1998 . 9520111 . 10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I . 43022919 .
• Pishvaian MJ, Feltes CM, Thompson P, Bussemakers MJ, Schalken JA, Byers SW . Cadherin-11 is expressed in invasive breast cancer cell lines. . Cancer Res. . 59 . 4 . 947–52 . 1999 . 10029089 .
• Kawaguchi J, Takeshita S, Kashima T, Imai T, Machinami R, Kudo A . Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11. . J. Bone Miner. Res. . 14 . 5 . 764–75 . 1999 . 10320525 . 10.1359/jbmr.1999.14.5.764 . 12829659 . free .
• Braungart E, Schumacher C, Hartmann E, Nekarda H, Becker KF, Höfler H, Atkinson MJ . Functional loss of E-cadherin and cadherin-11 alleles on chromosome 16q22 in colonic cancer. . J. Pathol. . 187 . 5 . 530–4 . 2000 . 10398117 . 10.1002/(SICI)1096-9896(199904)187:5<530::AID-PATH293>3.0.CO;2-C . 22384331 .
• Kashima T, Kawaguchi J, Takeshita S, Kuroda M, Takanashi M, Horiuchi H, Imamura T, Ishikawa Y, Ishida T, Mori S, Machinami R, Kudo A . Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis. . Am. J. Pathol. . 155 . 5 . 1549–55 . 1999 . 10550312 . 1866957 . 10.1016/S0002-9440(10)65471-5 .
• Lecanda F, Cheng SL, Shin CS, Davidson MK, Warlow P, Avioli LV, Civitelli R . Differential regulation of cadherins by dexamethasone in human osteoblastic cells. . J. Cell. Biochem. . 77 . 3 . 499–506 . 2000 . 10760957 . 10.1002/(SICI)1097-4644(20000601)77:3<499::AID-JCB14>3.0.CO;2-0 . 13331343 .
• Braungart E, Hartman E, Bechler K, Höfler H, Atkinson MJ . The intracellular domain of cadherin-11 is not required for the induction of cell aggregation, adhesion or gap-junction formation. . Cell Commun. Adhes. . 8 . 1 . 15–27 . 2002 . 11775026 . 10.3109/15419060109080704 . 23322445 .
• Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW . A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. . J. Cell Sci. . 116 . Pt 24 . 4985–95 . 2004 . 14625392 . 10.1242/jcs.00815 . free .
• Morimoto AM, Tan N, West K, McArthur G, Toner GC, Manning WC, Smolich BD, Cherrington JM . Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor. . Oncogene . 23 . 8 . 1618–26 . 2004 . 14985702 . 10.1038/sj.onc.1207268 . 23251484 .
• Marchong MN, Chen D, Corson TW, Lee C, Harmandayan M, Bowles E, Chen N, Gallie BL . Minimal 16q genomic loss implicates cadherin-11 in retinoblastoma. . Mol. Cancer Res. . 2 . 9 . 495–503 . 2005 . 10.1158/1541-7786.495.2.9 . 15383628 . 24674595 . free .
• Oliveira AM, Perez-Atayde AR, Inwards CY, Medeiros F, Derr V, Hsi BL, Gebhardt MC, Rosenberg AE, Fletcher JA . USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. . Am. J. Pathol. . 165 . 5 . 1773–80 . 2004 . 15509545 . 3278819 . 10.1016/S0002-9440(10)63432-3 .
• Kiener HP, Brenner MB . Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion. . . 7 . 2 . 49–54 . 2005 . 15743489 . 1065331 . 10.1186/ar1495 . free .
• Kiener HP, Lee DM, Agarwal SK, Brenner MB . Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro. . Am. J. Pathol. . 168 . 5 . 1486–99 . 2006 . 16651616 . 1606584 . 10.2353/ajpath.2006.050999 .

Notes and References

1. Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF . Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity . Genomics . 49 . 3 . 467–71 . Aug 1998 . 9615235 . 10.1006/geno.1998.5281 .
2. Web site: Entrez Gene: CDH11 cadherin 11, type 2, OB-cadherin (osteoblast).
3. Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P . Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain . Mol. Cell. Neurosci. . 17 . 1 . 151–66 . 2001 . 11161476 . 10.1006/mcne.2000.0937 . 30856590 .
4. Web site: New Therapeutic Approach Could Target Both Cancer and Arthritis . 15 Nov 2013 .
5. Assefnia S, Dakshanamurthy S, Guidry Auvil JM, Hampel C, Anastasiadis PZ, Kallakury B, Uren A, Foley DW, Brown ML, Shapiro L, Brenner M, Haigh D, Byers SW . Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. . Oncotarget . 5 . 6 . 1458–74 . Mar 2014 . 24681547 . 10.18632/oncotarget.1538 . 4039224.
6. Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW . A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells . J. Cell Sci. . 116 . Pt 24 . 4985–95 . Dec 2003 . 14625392 . 10.1242/jcs.00815 . free .