| Cache River State Natural Area | |
| Map: | Illinois#USA |
| Map Width: | 225 |
| Location: | Johnson County, Illinois, USA |
| Nearest City: | Belknap, Illinois |
| Coordinates: | 37.3622°N -88.9556°W |
| Established: | 1970 |
| Governing Body: | Illinois Department of Natural Resources |
Cache River State Natural Area is an Illinois state park centered on the Cache River (Illinois) of in Johnson County, Illinois, United States.