| Cabinet Name: | Strydom Cabinet |
| Cabinet Number: | 12th |
| Jurisdiction: | the Union of South Africa (since the 1909 South Africa Act) |
| Flag: | Flag of South Africa (1928–1982).svg |
| Flag Border: | true |
| Incumbent: | 1958–1961 |
| State Head Title: | Monarch |
| State Head: | Queen Elizabeth II |
| Governor General Title: | Governor-General |
| Government Head Title: | Prime Minister |
| Political Party: | National Party |
| Legislature Status: | Majority |
| Opposition Party: | United Party |
| Opposition Leader: | De Villiers Graaff |
| Election: | 1958 election |
| Previous: | Malan II |
| Successor: | Verwoerd I |
| Post | Minister | Term | Party | ||
|---|---|---|---|---|---|
| Prime Minister | Hendrik Verwoerd | 1958 | – | NP | |
| Johannes Strydom | 1958 | 1958 | NP | ||
| Deputy Prime Minister | Hendrik Verwoerd | 1958 | 1958 | NP | |
| Minister of Defence | The Hon. Jacobus Fouché MP | 1959 | – | NP | |
| The Hon. F. C. Erasmus MP | 1948 | 1959 | NP | ||
| Minister of Economic Affairs | The Hon. Nicolaas Diederichs MP | 1958 | – | NP | |
| Minister of Education, Arts and Science | The Hon. J. J. Serfontein MP | 1958 | 1961 | NP | |
| Minister of Finance | The Hon. Eben Dönges MP | 1958 | – | NP | |
| Minister of Foreign Affairs | The Hon. E. H. Louw MP | 1955 | – | NP | |
| Minister of Forestry | The Hon. F. C. Erasmus MP | 1956 | 1959 | NP | |
| Minister of Health | The Hon. Albert Hertzog MP | 1958 | – | NP | |
| Minister of Interior Affairs | The Hon. Tom Naudé MP | 1958 | 1961 | NP | |
| Minister of Justice | The Hon. F. C. Erasmus MP | 1959 | – | NP | |
| The Hon. Charles Swart MP | 1948 | 1959 | NP | ||
| Minister of Labour | The Hon. Jan de Klerk MP | 1954 | 1961 | NP | |
| Minister of Lands and Irrigation | The Hon. P. O. Sauer MP | 1954 | – | NP | |
| Minister of Posts and Telegraphs | The Hon. Albert Hertzog MP | 1954 | – | NP | |
| Minister of Public Works | The Hon. P. O. Sauer MP | 1958 | – | NP | |
| Minister of Social Welfare and Pensions | The Hon. J. J. Serfontein MP | 1954 | – | NP | |
| Minister of Transport | The Hon. B. J. Schoeman MP | 1954 | – | NP | |
| Minister of Water Affairs and Agricultural Technical Services | The Hon. P. K. le Roux MP | 1958 | – | NP | |