PSCDBP explained

Cytohesin-interacting protein is a protein that in humans is encoded by the CYTIP gene.^{[1] [2] [3] [4]}

The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, and it does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells.

Further reading

• Mansour M, Lee SY, Pohajdak B . The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP. . J. Biol. Chem. . 277 . 35 . 32302–9 . 2002 . 12052827 . 10.1074/jbc.M202898200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Boehm T, Hofer S, Winklehner P, etal . Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration. . EMBO J. . 22 . 5 . 1014–24 . 2003 . 12606567 . 10.1093/emboj/cdg101 . 150334 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4. . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .
• Chen Q, Coffey A, Bourgoin SG, Gadina M . Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway. . J. Biol. Chem. . 281 . 29 . 19985–94 . 2006 . 16702224 . 10.1074/jbc.M601629200 . free .
• MacNeil AJ, Mansour M, Pohajdak B . Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes. . Biochem. Biophys. Res. Commun. . 359 . 4 . 848–53 . 2007 . 17577583 . 10.1016/j.bbrc.2007.05.162 .

Notes and References

1. Dixon B, Sahely B, Liu L, Pohajdak B . Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein . Biochim Biophys Acta . 1216 . 2 . 321–4 . Jan 1994 . 8241278 . 10.1016/0167-4781(93)90165-a.
2. Kim HS . Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping . Cytogenet Cell Genet . 84 . 1–2 . 95 . Jun 1999 . 10343115 . 10.1159/000015226 . 7420858 .
3. Tang P, Cheng TP, Agnello D, Wu CY, Hissong BD, Watford WT, Ahn HJ, Galon J, Moss J, Vaughan M, O'Shea JJ, Gadina M . Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity . Proc Natl Acad Sci USA . 99 . 5 . 2625–9 . Mar 2002 . 11867758 . 122398 . 10.1073/pnas.052712999 . 2002PNAS...99.2625T . free .
4. Web site: Entrez Gene: PSCDBP pleckstrin homology, Sec7 and coiled-coil domains, binding protein.