CYTH3 explained

Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.^{[1] [2]}

This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Cytohesin family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.

Further reading

• Franco M . ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function . Proc. Natl. Acad. Sci. U.S.A. . 95 . 17 . 9926–31 . 1998 . 9707577 . 10.1073/pnas.95.17.9926 . 21438 . vanc. Boretto J . Robineau S . 3 . Monier . S . Goud . B . Chardin . P . Chavrier . P . 1998PNAS...95.9926F . free .
• Venkateswarlu K . Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain . Biochem. J. . 335 (Pt 1) . Pt 1. 139–46 . 1998 . 9742223 . 10.1042/bj3350139. 1219762 . vanc. Gunn-Moore F . Oatey PB . 3 . Tavaré . JM . Cullen . PJ .
• Ogasawara M . Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors . J. Biol. Chem. . 275 . 5 . 3221–30 . 2000 . 10652308 . 10.1074/jbc.275.5.3221 . vanc. Kim SC . Adamik R . 3 . Togawa . A . Ferrans . VJ . Takeda . K . Kirby . M . Moss . J . Vaughan . M . free .
• Nevrivy DJ . Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors . J. Biol. Chem. . 275 . 22 . 16827–36 . 2000 . 10828067 . 10.1074/jbc.275.22.16827 . vanc. Peterson VJ . Avram D . 3 . Ishmael . JE . Hansen . SG . Dowell . P . Hruby . DE . Dawson . MI . Leid . M . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Scherer SW . Human Chromosome 7: DNA Sequence and Biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . vanc. Cheung J . MacDonald JR . 3 . Osborne . LR . Nakabayashi . K . Herbrick . JA . Carson . AR . Parker-Katiraee . L . Skaug . J . 2003Sci...300..767S .
• Hillier LW . The DNA sequence of human chromosome 7 . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . vanc. Fulton RS . Fulton LA . 3 . Graves . Tina A. . Pepin . Kymberlie H. . Wagner-Mcpherson . Caryn . Layman . Dan . Maas . Jason . Jaeger . Sara . 2003Natur.424..157H . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Poirier MB . General receptor for phosphoinositides 1, a novel repressor of thyroid hormone receptor action that prevents deoxyribonucleic acid binding . Mol. Endocrinol. . 19 . 8 . 1991–2005 . 2005 . 15878955 . 10.1210/me.2004-0449 . vanc. Hamann G . Domingue ME . 3 . Roy . M . Bardati . T . Langlois . MF . free.
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Klarlund JK, Guilherme A, Holik JJ, Virbasius JV, Chawla A, Czech MP . Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains . Science . 275 . 5308 . 1927–30 . Apr 1997 . 9072969 . 10.1126/science.275.5308.1927 . 40523716 .
2. Web site: Entrez Gene: PSCD3 pleckstrin homology, Sec7 and coiled-coil domains 3.