CYP9 family explained

Cytochrome P450, family 9, also known as CYP9, is a cytochrome P450 family found in Insect genome,^{[1] [2]} CYP9 and insect CYP6 family belong to the same clan as mammalian CYP3 and CYP5 families.^[3] The first gene identified in this family is the CYP9A1 from the Heliothis virescens (tobacco budworm), which is involved in thiodicarb insecticide resistance.^[4] Subfamily CYP9A in Lepidopteran play important roles in insecticide resistance, can metabolize esfenvalerate efficiently.^[5]

Notes and References

1. Stevens . JL . Snyder . MJ . Koener . JF . Feyereisen . R . Inducible P450s of the CYP9 family from larval Manduca sexta midgut. . Insect Biochemistry and Molecular Biology . July 2000 . 30 . 7 . 559–68 . 10.1016/s0965-1748(00)00024-2 . 10844248.
2. Ishak . IH . Kamgang . B . Ibrahim . SS . Riveron . JM . Irving . H . Wondji . CS . Pyrethroid Resistance in Malaysian Populations of Dengue Vector Aedes aegypti Is Mediated by CYP9 Family of Cytochrome P450 Genes. . PLOS Neglected Tropical Diseases . January 2017 . 11 . 1 . e0005302 . 10.1371/journal.pntd.0005302 . 28114328. 5289618 . free .
3. Nelson . DR . Metazoan cytochrome P450 evolution. . Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology . November 1998 . 121 . 1–3 . 15–22 . 10.1016/s0742-8413(98)10027-0 . 9972448.
4. Rose . RL . Goh . D . Thompson . DM . Verma . KD . Heckel . DG . Gahan . LJ . Roe . RM . Hodgson . E . Cytochrome P450 (CYP)9A1 in Heliothis virescens: the first member of a new CYP family. . Insect Biochemistry and Molecular Biology . June 1997 . 27 . 6 . 605–15 . 10.1016/s0965-1748(97)00036-2 . 9304798.
5. Shi . Y . Jiang . Q . Yang . Y . Feyereisen . R . Wu . Y . Pyrethroid metabolism by eleven Helicoverpa armigera P450s from the CYP6B and CYP9A subfamilies. . Insect Biochemistry and Molecular Biology . August 2021 . 135 . 103597 . 10.1016/j.ibmb.2021.103597 . 34089822. 235353940 .