CYP6 family explained

Cytochrome P450, family 6, also known as CYP6, is a cytochrome P450 family found in Insect genome. CYP6 and CYP9, another insect CYP family, belong to the same clan as mammalian CYP3 and CYP5 families.^[1]

The first two CYP6 subfamilies represented by CYP6A1 and CYP6B1 shared only 32.7% identity,^[2] less than the typical CYP subfamilies, which share at least 40% amino acid identity.^[3]

Many of the enzymes in this family like CYP6G1 (DDT-R) in Drosophila melanogaster^[4] and CYP6B in Helicoverpa armigera^[5] are related to insecticide resistance.

Notes and References

1. Nelson . DR . Metazoan cytochrome P450 evolution. . Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology . November 1998 . 121 . 1–3 . 15–22 . 10.1016/s0742-8413(98)10027-0 . 9972448.
2. Dermauw . W . Van Leeuwen . T . Feyereisen . R . Diversity and evolution of the P450 family in arthropods. . Insect Biochemistry and Molecular Biology . December 2020 . 127 . 103490 . 10.1016/j.ibmb.2020.103490 . 33169702. 226297890 . free . 1854/LU-8689608 . free .
3. Book: Nelson . DR . Cytochrome P450 Protocols . Cytochrome P450 Nomenclature, 2004 . Methods in Molecular Biology . 2006 . 320 . 1–10 . 10.1385/1-59259-998-2:1 . 16719369. 1-59259-998-2 .
4. Le Goff . G . Hilliou . F . Resistance evolution in Drosophila: the case of CYP6G1. . Pest Management Science . March 2017 . 73 . 3 . 493–499 . 10.1002/ps.4470 . 27787942.
5. Shi . Y . Jiang . Q . Yang . Y . Feyereisen . R . Wu . Y . Pyrethroid metabolism by eleven Helicoverpa armigera P450s from the CYP6B and CYP9A subfamilies. . Insect Biochemistry and Molecular Biology . August 2021 . 135 . 103597 . 10.1016/j.ibmb.2021.103597 . 34089822. 235353940 .