CYP3A43 explained

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.^{[1] [2] [3]}

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.

Further reading

• Smith G, Stubbins MJ, Harries LW, Wolf CR . Molecular genetics of the human cytochrome P450 monooxygenase superfamily . Xenobiotica . 28 . 12 . 1129–65 . 1999 . 9890157 . 10.1080/004982598238868 .
• Finta C, Zaphiropoulos PG . The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons . Gene . 260 . 1–2 . 13–23 . 2001 . 11137287 . 10.1016/S0378-1119(00)00470-4 .
• Westlind A, Malmebo S, Johansson I . Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43 . Biochem. Biophys. Res. Commun. . 281 . 5 . 1349–55 . 2001 . 11243885 . 10.1006/bbrc.2001.4505 . etal.
• Finta C, Zaphiropoulos PG . Intergenic mRNA molecules resulting from trans-splicing . J. Biol. Chem. . 277 . 8 . 5882–90 . 2002 . 11726664 . 10.1074/jbc.M109175200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Hillier LW, Fulton RS, Fulton LA . The DNA sequence of human chromosome 7 . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . etal. free .
• Cauffiez C, Lo-Guidice JM, Chevalier D . First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant . Hum. Mutat. . 23 . 1 . 101 . 2004 . 14695544 . 10.1002/humu.9211 . 9162733 . etal. free .
• Hillman RT, Green RE, Brenner SE . An unappreciated role for RNA surveillance . Genome Biol. . 5 . 2 . R8 . 2005 . 14759258 . 10.1186/gb-2004-5-2-r8 . 395752 . free .
• Stone A, Ratnasinghe LD, Emerson GL . CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians . Cancer Epidemiol. Biomarkers Prev. . 14 . 5 . 1257–61 . 2005 . 15894682 . 10.1158/1055-9965.EPI-04-0534 . etal. free .
• Thompson EE, Kuttab-Boulos H, Yang L . Sequence diversity and haplotype structure at the human CYP3A cluster . Pharmacogenomics J. . 6 . 2 . 105–14 . 2006 . 16314882 . 10.1038/sj.tpj.6500347 . etal. free .
• Shchepotina EG, Nikishina MV, Vavilin VA, Lyakhovich VV . Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia . Bull. Exp. Biol. Med. . 140 . 6 . 726–8 . 2006 . 16848237 . 10.1007/s10517-006-0067-6 . 11922749 .

Notes and References

1. Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG . cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450 . Mol Pharmacol . 59 . 2 . 386–92 . Feb 2001 . 11160876 . 10.1124/mol.59.2.386.
2. Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L . Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene . Pharmacogenetics . 11 . 2 . 111–21 . Mar 2001 . 11266076 . 10.1097/00008571-200103000-00002 .
3. Web site: Entrez Gene: CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43.