CYP2W1 explained

CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.^[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Hanzawa Y, Sasaki T, Mizugaki M . Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population . Drug Metab. Dispos. . 36 . 2 . 349–52 . 2008 . 17998294 . 10.1124/dmd.107.019141 . 5123383 . etal.
• Yoshioka H, Kasai N, Ikushiro S . Enzymatic properties of human CYP2W1 expressed in Escherichia coli . Biochem. Biophys. Res. Commun. . 345 . 1 . 169–74 . 2006 . 16677611 . 10.1016/j.bbrc.2006.04.080 . etal.
• Karlgren M, Gomez A, Stark K . Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1 . Biochem. Biophys. Res. Commun. . 341 . 2 . 451–8 . 2006 . 16426568 . 10.1016/j.bbrc.2005.12.200 . etal.
• Gomez A, Karlgren M, Edler D . Expression of CYP2W1 in colon tumors: regulation by gene methylation . Pharmacogenomics . 8 . 10 . 1315–25 . 2007 . 17979506 . 10.2217/14622416.8.10.1315 . etal.
• Nelson DR, Zeldin DC, Hoffman SM . Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants . Pharmacogenetics . 14 . 1 . 1–18 . 2004 . 15128046 . 10.1097/00008571-200401000-00001 . etal.

Notes and References

1. Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . October 2004 . 15489334 . 528928 . 10.1101/gr.2596504 . etal.