CYP2A13 explained

Cytochrome P450 2A13 is a protein that in humans is encoded by the CYP2A13 gene.^{[1] [2]}

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.^[3]

Further reading

• Fernandez-Salguero P, Gonzalez FJ . The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis. . Pharmacogenetics . 5 . Special Issue . S123–8 . 1995 . 7581481 . 10.1097/00008571-199512001-00013 .
• Smith G, Stubbins MJ, Harries LW, Wolf CR . Molecular genetics of the human cytochrome P450 monooxygenase superfamily. . Xenobiotica . 28 . 12 . 1129–65 . 1999 . 9890157 . 10.1080/004982598238868 .
• Hoffman SM, Fernandez-Salguero P, Gonzalez FJ, Mohrenweiser HW . Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19. . J. Mol. Evol. . 41 . 6 . 894–900 . 1996 . 8587134 . 10.1007/bf00173169. 12153961 .
• Koskela S, Hakkola J, Hukkanen J . Expression of CYP2A genes in human liver and extrahepatic tissues. . Biochem. Pharmacol. . 57 . 12 . 1407–13 . 1999 . 10353262 . 10.1016/S0006-2952(99)00015-5 . etal.
• Su T, Bao Z, Zhang QY . Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. . Cancer Res. . 60 . 18 . 5074–9 . 2000 . 11016631 . etal.
• Zhang X, Su T, Zhang QY . Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant. . J. Pharmacol. Exp. Ther. . 302 . 2 . 416–23 . 2002 . 12130698 . 10.1124/jpet.302.2.416 . etal.
• Saito S, Iida A, Sekine A . Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. . J. Hum. Genet. . 48 . 5 . 249–70 . 2003 . 12721789 . 10.1007/s10038-003-0021-7 . etal. free .
• Wang H, Tan W, Hao B . Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK. . Cancer Res. . 63 . 22 . 8057–61 . 2004 . 14633739 . etal.
• Cauffiez C, Lo-Guidice JM, Quaranta S . Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility. . Biochem. Biophys. Res. Commun. . 317 . 2 . 662–9 . 2004 . 15063809 . 10.1016/j.bbrc.2004.03.092 . etal.
• Cheng XY, Chen GL, Zhang WX . Arg257Cys polymorphism of CYP2A13 in a Chinese population. . Clin. Chim. Acta . 343 . 1–2 . 213–6 . 2004 . 15115698 . 10.1016/j.cccn.2004.01.017 . etal.
• He XY, Shen J, Ding X . Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen . Drug Metab. Dispos. . 32 . 12 . 1516–21 . 2005 . 15333516 . 10.1124/dmd.104.001370 . 26225467 . etal.
• Fujieda M, Yamazaki H, Kiyotani K . Eighteen novel polymorphisms of the CYP2A13 gene in Japanese . Drug Metab. Pharmacokinet. . 18 . 1 . 86–90 . 2005 . 15618722 . 10.2133/dmpk.18.86 . etal.
• Smith BD, Sanders JL, Porubsky PR . Structure of the human lung cytochrome P450 2A13 . J. Biol. Chem. . 282 . 23 . 17306–13 . 2007 . 17428784 . 10.1074/jbc.M702361200 . etal. free .

Notes and References

1. Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR . A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles . Am J Hum Genet . 57 . 3 . 651–60 . Oct 1995 . 7668294 . 1801261 . etal.
2. Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW . Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants . Pharmacogenetics . 14 . 1 . 1–18 . May 2004 . 15128046 . 10.1097/00008571-200401000-00001 .
3. Web site: Entrez Gene: CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13.