CYP27 family explained

Cytochrome P450, family 27, also known as CYP27, is a Deuterostome cytochrome P450 monooxygenase family found in human genome.[1] [2] This family belongs to Mitochondrial clan CYPs, which is located in the inner membrane of mitochondria(IMM). There are three members in the human genome, CYP27A1, CYP27B1 and CYP27C1,[3] and an ortholog CYP27F1 in sea urchins, Strongylocentrotus purpuratus.[4]

Notes and References

  1. Baker . Michael E. . Nelson . David R. . Studer . Romain A. . Origin of the response to adrenal and sex steroids: Roles of promiscuity and co-evolution of enzymes and steroid receptors . The Journal of Steroid Biochemistry and Molecular Biology . July 2015 . 151 . 12–24 . 10.1016/j.jsbmb.2014.10.020. 25445914 . 21649057 .
  2. Peterson . Julian A . Graham . Sandra E . 1998 . A close family resemblance: the importance of structure in understanding cytochromes P450 . Structure . en . 6 . 9 . 1079–1085 . 10.1016/S0969-2126(98)00109-9. 9753700 . free .
  3. Rendic . Slobodan . Carlo . Frederick J. Di . 1997 . Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors . Drug Metabolism Reviews . en . 29 . 1–2 . 413–580 . 10.3109/03602539709037591 . 9187528 . 0360-2532.
  4. Sea Urchin Genome Sequencing . Consortium. . Sodergren . E . Weinstock . GM . Davidson . EH . Cameron . RA . Gibbs . RA . Angerer . RC . Angerer . LM . Arnone . MI . Burgess . DR . Burke . RD . Coffman . JA . Dean . M . Elphick . MR . Ettensohn . CA . Foltz . KR . Hamdoun . A . Hynes . RO . Klein . WH . Marzluff . W . McClay . DR . Morris . RL . Mushegian . A . Rast . JP . Smith . LC . Thorndyke . MC . Vacquier . VD . Wessel . GM . Wray . G . Zhang . L . Elsik . CG . Ermolaeva . O . Hlavina . W . Hofmann . G . Kitts . P . Landrum . MJ . Mackey . AJ . Maglott . D . Panopoulou . G . Poustka . AJ . Pruitt . K . Sapojnikov . V . Song . X . Souvorov . A . Solovyev . V . Wei . Z . Whittaker . CA . Worley . K . Durbin . KJ . Shen . Y . Fedrigo . O . Garfield . D . Haygood . R . Primus . A . Satija . R . Severson . T . Gonzalez-Garay . ML . Jackson . AR . Milosavljevic . A . Tong . M . Killian . CE . Livingston . BT . Wilt . FH . Adams . N . Bellé . R . Carbonneau . S . Cheung . R . Cormier . P . Cosson . B . Croce . J . Fernandez-Guerra . A . Genevière . AM . Goel . M . Kelkar . H . Morales . J . Mulner-Lorillon . O . Robertson . AJ . Goldstone . JV . Cole . B . Epel . D . Gold . B . Hahn . ME . Howard-Ashby . M . Scally . M . Stegeman . JJ . Allgood . EL . Cool . J . Judkins . KM . McCafferty . SS . Musante . AM . Obar . RA . Rawson . AP . Rossetti . BJ . Gibbons . IR . Hoffman . MP . Leone . A . Istrail . S . Materna . SC . Samanta . MP . 1 . Stolc . V . Tongprasit . W . Tu . Q . Bergeron . KF . Brandhorst . BP . Whittle . J . Berney . K . Bottjer . DJ . Calestani . C . Peterson . K . Chow . E . Yuan . QA . Elhaik . E . Graur . D . Reese . JT . Bosdet . I . Heesun . S . Marra . MA . Schein . J . Anderson . MK . Brockton . V . Buckley . KM . Cohen . AH . Fugmann . SD . Hibino . T . Loza-Coll . M . Majeske . AJ . Messier . C . Nair . SV . Pancer . Z . Terwilliger . DP . Agca . C . Arboleda . E . Chen . N . Churcher . AM . Hallböök . F . Humphrey . GW . Idris . MM . Kiyama . T . Liang . S . Mellott . D . Mu . X . Murray . G . Olinski . RP . Raible . F . Rowe . M . Taylor . JS . Tessmar-Raible . K . Wang . D . Wilson . KH . Yaguchi . S . Gaasterland . T . Galindo . BE . Gunaratne . HJ . Juliano . C . Kinukawa . M . Moy . GW . Neill . AT . Nomura . M . Raisch . M . Reade . A . Roux . MM . Song . JL . Su . YH . Townley . IK . Voronina . E . Wong . JL . Amore . G . Branno . M . Brown . ER . Cavalieri . V . Duboc . V . Duloquin . L . Flytzanis . C . Gache . C . Lapraz . F . Lepage . T . Locascio . A . Martinez . P . Matassi . G . Matranga . V . Range . R . Rizzo . F . Röttinger . E . Beane . W . Bradham . C . Byrum . C . Glenn . T . Hussain . S . Manning . G . Miranda . E . Thomason . R . Walton . K . Wikramanayke . A . Wu . SY . Xu . R . Brown . CT . Chen . L . Gray . RF . Lee . PY . Nam . J . Oliveri . P . Smith . J . Muzny . D . Bell . S . Chacko . J . Cree . A . Curry . S . Davis . C . Dinh . H . Dugan-Rocha . S . Fowler . J . Gill . R . Hamilton . C . Hernandez . J . Hines . S . Hume . J . Jackson . L . Jolivet . A . Kovar . C . Lee . S . Lewis . L . Miner . G . Morgan . M . Nazareth . LV . Okwuonu . G . Parker . D . Pu . LL . Thorn . R . Wright . R . The genome of the sea urchin Strongylocentrotus purpuratus. . Science . 10 November 2006 . 314 . 5801 . 941–52 . 10.1126/science.1133609 . 17095691. 3159423 . 2006Sci...314..941S . 10447/16293 . 206508576 . free .

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