CYP26C1 explained

CYP26C1 (cytochrome P450, family 26, subfamily c, polypeptide 1) is a protein which in humans is encoded by the CYP26C1 gene.^[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues.

CYP26C1 was found to show no expression in colorectal cancer cells or normal colonic epithelium.^[2]

Further reading

• Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . etal. free .
• Rat E, Billaut-Laden I, Allorge D . Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida. . Birth Defects Res. A . 76 . 6 . 491–8 . 2006 . 16933217 . 10.1002/bdra.20275 . etal.
• Nelson DR, Zeldin DC, Hoffman SM . Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. . Pharmacogenetics . 14 . 1 . 1–18 . 2004 . 15128046 . 10.1097/00008571-200401000-00001 . etal.
• Wan C, Shi Y, Zhao X . Positive association between ALDH1A2 and schizophrenia in the Chinese population. . Prog. Neuropsychopharmacol. Biol. Psychiatry . 33 . 8 . 1491–5 . 2009 . 19703508 . 10.1016/j.pnpbp.2009.08.008 . 32862839 . etal.
• Grupe A, Li Y, Rowland C . A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. . Am. J. Hum. Genet. . 78 . 1 . 78–88 . 2006 . 16385451 . 10.1086/498851 . 1380225 . etal.

Notes and References

1. Taimi M, Helvig C, Wisniewski J . A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid . J. Biol. Chem. . 279 . 1 . 77–85 . January 2004 . 14532297 . 10.1074/jbc.M308337200 . etal. free .
2. Brown. Gordon. Beatriz Cash . Daniela Blihoghe . Petronella Johansson . Ayham Alnabulsi . Graeme Murray . The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer. PLOS ONE. 2014-03-07. 10.1371/journal.pone.0090776. 24608339 . 3946526 . 9 . 3. e90776. 2014PLoSO...990776B. free.