CYP20A1 explained

CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1) is a protein which in humans is encoded by the CYP20A1 gene.^[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in pollutant and drug metabolism and the synthesis of cholesterol, steroids, and other lipids. CYP20A1 lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen.

CYP20A1 has no identified substrate or biological role and is considered an "orphan" P450.

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Jiang JH, Jia WH, Qin HD . [Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue] . AI Zheng . 23 . 6 . 672–7 . 2004 . 15191668 . etal.
• Werck-Reichhart D, Feyereisen R . Cytochromes P450: a success story. . Genome Biol. . 1 . 6 . REVIEWS3003 . 2000 . 11178272 . 10.1186/gb-2000-1-6-reviews3003 . 138896 . free .
• Ross CJ, Katzov-Eckert H, Dubé MP . Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. . Nat. Genet. . 41 . 12 . 1345–9 . 2009 . 19898482 . 10.1038/ng.478 . 21293339 . etal.
• Nelson DR, Zeldin DC, Hoffman SM . Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. . Pharmacogenetics . 14 . 1 . 1–18 . 2004 . 15128046 . 10.1097/00008571-200401000-00001 . etal.
• Smith G, Stubbins MJ, Harries LW, Wolf CR . Molecular genetics of the human cytochrome P450 monooxygenase superfamily. . Xenobiotica . 28 . 12 . 1129–65 . 1998 . 9890157 . 10.1080/004982598238868 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .

Notes and References

1. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Res. . 13 . 10 . 2265–70 . October 2003 . 12975309 . 403697 . 10.1101/gr.1293003 .