CYP13 family explained
Cytochrome P450, family 13, also known as CYP13, is a nematoda cytochrome P450 monooxygenase family.[1] The first gene identified in this family is the CYP13A1 from the Caenorhabditis elegans.
CYP13 can be divided into subfamily CYP13A and CYP13B,[1] and the CYP13B was named CYP16 family at the beginning of its discovery, which have been discontinued and been changed to the current name, because its genetic relationship with the subfamily CYP13A.[2]
Genes in C. elegans
Gene | Biological Functions | Protein Length | Ref |
---|
CYP13A1 | | 519 | |
CYP13A2 | | 515 | |
CYP13A3 | | 520 | |
CYP13A4 | | 520 | |
CYP13A5 | | 520 | |
CYP13A6 | | 518 | |
CYP13A7 | Dauer formation, Detoxication | 518 | |
CYP13A8 | Acidic Stress | 509 | [3] |
CYP13A9 | | |
CYP13A10 | | 519 | |
CYP13A11 | | 517 | |
CYP13A12 | | 518 | [4] |
CYP13B1 | | 510 | |
CYP13B2 | | 511 | | |
Notes and References
- Larigot . L . Mansuy . D . Borowski . I . Coumoul . X . Dairou . J . Cytochromes P450 of Caenorhabditis elegans: Implication in Biological Functions and Metabolism of Xenobiotics. . Biomolecules . 22 February 2022 . 12 . 3 . 342 . 10.3390/biom12030342 . 35327534. 8945457 . free .
- Nelson . DR . Metazoan cytochrome P450 evolution. . Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology . November 1998 . 121 . 1–3 . 15–22 . 10.1016/s0742-8413(98)10027-0 . 9972448.
- Cong . Yanyi . Yang . Hanwen . Zhang . Pengchi . Xie . Yusu . Cao . Xuwen . Zhang . Liusuo . Transcriptome Analysis of the Nematode Caenorhabditis elegans in Acidic Stress Environments . Frontiers in Physiology . 10 September 2020 . 11 . 1107 . 10.3389/fphys.2020.01107. 33013473 . 7511720 . free .
- Keller . J . Ellieva . A . Ma . DK . Ju . J . Nehk . E . Konkel . A . Falck . JR . Schunck . WH . Menzel . R . CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation. . The Biochemical Journal . 15 November 2014 . 464 . 1 . 61–71 . 10.1042/BJ20140848 . 25138176.