CYP11 family explained

Cytochrome P450, family 11, also known as CYP11, is a chordate cytochrome P450 monooxygenase family. This family contains many enzymes involved in steroidogenesis, such as Cholesterol side-chain cleavage enzyme (CYP11A1), Steroid 11β-hydroxylase (CYP11B1) and Aldosterone synthase (CYP11B2).^[1] CYP11 can be divided into A to E five subfamilies,^[2] and CYP11A are the ohonologues to CYP11C, which duplicated during 2R event, and the tetrapod's CYP11B evolved from CYP11C of its fish ancestors,^[3] CYP11D and F found in amphioxus.^[2] These are not the typical CYP subfamilies, which share at least 40% amino acid identity,^[4] members between CYP11A and B subfamily are only 37.5-38.8% identical,^[5] and the CYP11D and E genes seen in modern lancelet (Branchiostoma floridae, an ancient branch of chordate animals) is 39% identical to catfish CYP11A1.^{[3] [2]}

Notes and References

1. Omura . T . Mitochondrial P450s. . Chemico-Biological Interactions . 27 October 2006 . 163 . 1–2 . 86–93 . 10.1016/j.cbi.2006.06.008 . 16884708. 2006CBI...163...86O .
2. Baker . ME . Nelson . DR . Studer . RA . Origin of the response to adrenal and sex steroids: Roles of promiscuity and co-evolution of enzymes and steroid receptors. . The Journal of Steroid Biochemistry and Molecular Biology . July 2015 . 151 . 12–24 . 10.1016/j.jsbmb.2014.10.020 . 25445914. 21649057 .
3. Nelson DR, Goldstone JV, Stegeman JJ . The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s . Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences . 368 . 1612 . 20120474 . February 2013 . 23297357 . 3538424 . 10.1098/rstb.2012.0474 .
4. Book: Nelson . DR . Cytochrome P450 Protocols . Cytochrome P450 Nomenclature, 2004 . Methods in Molecular Biology . 2006 . 320 . 1–10 . 10.1385/1-59259-998-2:1 . 16719369. 1-59259-998-2 .
5. Nebert . DW . Nelson . DR . Adesnik . M . Coon . MJ . Estabrook . RW . Gonzalez . FJ . Guengerich . FP . Gunsalus . IC . Johnson . EF . Kemper . B . The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. . DNA (Mary Ann Liebert, Inc.) . January 1989 . 8 . 1 . 1–13 . 10.1089/dna.1.1989.8.1 . 2651058.