CYP11C1 explained

cytochrome P450, family 11, subfamily c, polypeptide 1
Organism:	Danio rerio
Taxid:	7955
Symbol:	CYP11C1
Entrezgene:	791124
Homologene:	128035
Refseqmrna:	NM_001080204.1
Refseqprotein:	NP_001073673.1
Uniprot:	A1XRK1
Ecnumber:	1.14.15.4
Chromosome:	16
Entrezchromosome:	NC_007127.7
Genloc Start:	54456937
Genloc End:	54475946

The Cyp11c1 is a fish gene encoding a CYP450 enzyme, which was originally found in Zebrafish (Danio rerio), this enzyme mainly catalyze the formation of cortisol and 11-Ketotestosterone (11-KT).^[1] 11-KT is the endogenous androgen in zebrafish.^[2] CYP11C is the orthologous to CYP11B, tetrapod's CYP11B1 evolved from CYP11C1 of fish, and CYP11B/11C are the ohonologues to CYP11A, which duplicated during 2R event.^[3]

Notes and References

1. Zhang Q, Ye D, Wang H, Wang Y, Hu W, Sun Y . Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction . Endocrinology . 161 . 6 . June 2020 . 32222764 . 10.1210/endocr/bqaa048 . 214716321 . free .
2. Zheng Q, Xiao H, Shi H, Wang T, Sun L, Tao W, Kocher TD, Li M, Wang D . 6 . Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone . The Journal of Endocrinology . 244 . 3 . 487–499 . March 2020 . 31910154 . 10.1530/JOE-19-0438 . free .
3. Nelson DR, Goldstone JV, Stegeman JJ . The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s . Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences . 368 . 1612 . 20120474 . February 2013 . 23297357 . 3538424 . 10.1098/rstb.2012.0474 .