CYP11A2 explained
| cytochrome P450, family 11, subfamily a, polypeptide 2 |
| Organism: | Danio rerio |
| Taxid: | 7955 |
| Symbol: | CYP11A2 |
| Entrezgene: | 563363 |
| Homologene: | 37347 |
| Refseqmrna: | XM_686725.7 |
| Refseqprotein: | XP_691817.1 |
| Uniprot: | F1R1K0 |
| Ecnumber: | 1.14.15.6 |
| Chromosome: | 25 |
| Entrezchromosome: | NC_007136.7 |
| Genloc Start: | 22296390 |
| Genloc End: | 22311561 |
The Cyp11a2 is a fish gene encoding a CYP450 monooxygenase,[1] which was originally identified in Zebrafish (Danio rerio),[2] is the isozyme and paralogous of fish CYP11A1, catalyzes conversion of cholesterol to pregnenolone.[3]
Notes and References
- Uno T, Ishizuka M, Itakura T . Cytochrome P450 (CYP) in fish . Environmental Toxicology and Pharmacology . 34 . 1 . 1–13 . July 2012 . 22418068 . 10.1016/j.etap.2012.02.004 . 2012EnvTP..34....1U .
- Parajes S, Griffin A, Taylor AE, Rose IT, Miguel-Escalada I, Hadzhiev Y, Arlt W, Shackleton C, Müller F, Krone N . Redefining the initiation and maintenance of zebrafish interrenal steroidogenesis by characterizing the key enzyme cyp11a2 . Endocrinology . 154 . 8 . 2702–11 . August 2013 . 23671259 . 10.1210/en.2013-1145 . free .
- Li N, Oakes JA, Storbeck KH, Cunliffe VT, Krone NP . The P450 side-chain cleavage enzyme Cyp11a2 facilitates steroidogenesis in zebrafish . The Journal of Endocrinology . 244 . 2 . 309–321 . February 2020 . 31693487 . 10.1530/JOE-19-0384 . free .
