CYP109 family explained

Cytochrome P450, family 109, also known as CYP109, is a cytochrome P450 monooxygenase family,[1] many members are associated with fatty acid hydroxylation.[2] The first gene identified in this family is the CYP109A1 and CYP109B1 from Bacillus subtilis.[3] CYP109 is one of the only three P450 familis shared in bacteria and archaea, the other two are CYP147 and CYP197.[1] Genes in this family are co-present on archaeal plasmids and chromosomes, implying the plasmid-mediated horizontal gene transfer of these genes from bacteria to archaea.[1]

Notes and References

  1. Ngcobo . PE . Nkosi . BVZ . Chen . W . Nelson . DR . Syed . K . Evolution of Cytochrome P450 Enzymes and Their Redox Partners in Archaea. . International Journal of Molecular Sciences . 19 February 2023 . 24 . 4 . 4161 . 10.3390/ijms24044161 . free . 36835573. 9962201 .
  2. Khatri . Y . Hannemann . F . Girhard . M . Kappl . R . Même . A . Ringle . M . Janocha . S . Leize-Wagner . E . Urlacher . VB . Bernhardt . R . Novel family members of CYP109 from Sorangium cellulosum So ce56 exhibit characteristic biochemical and biophysical properties. . Biotechnology and Applied Biochemistry . January 2013 . 60 . 1 . 18–29 . 10.1002/bab.1087 . 23586989.
  3. Girhard M, Klaus T, Khatri Y, Bernhardt R, Urlacher VB . Characterization of the versatile monooxygenase CYP109B1 from Bacillus subtilis . Applied Microbiology and Biotechnology . 87 . 2 . 595–607 . June 2010 . 20186410 . 10.1007/s00253-010-2472-z . 26265331 .

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