CYP107 family explained

Cytochrome P450, family 107, also known as CYP107, is a cytochrome P450 monooxygenase family in bacteria,[1] [2] found to be conserved and highly populated in Streptomyces and Bacillus species.[3] The first gene identified in this family is Cytochrome P450 eryF (CYP107A1) from Saccharopolyspora erythraea.[4] Many enzymes of this family are involved in the synthesis of macrolide antibiotics.[1] [5] The members of this family are widely distributed in Alphaproteobacteria, cyanobacterial, Mycobacterium, Bacillota, and Streptomyces species, which may be due to horizontal gene transfer driven by selection pressure.[6]

Notes and References

  1. Padayachee . T . Lamb . DC . Nelson . DR . Syed . K . Structure-Function Analysis of the Biotechnologically Important Cytochrome P450 107 (CYP107) Enzyme Family. . Biomolecules . 1 December 2023 . 13 . 12 . 1733 . 10.3390/biom13121733 . free . 38136604. 10741444 .
  2. Nebert . DW . Nelson . DR . Coon . MJ . Estabrook . RW . Feyereisen . R . Fujii-Kuriyama . Y . Gonzalez . FJ . Guengerich . FP . Gunsalus . IC . Johnson . EF . The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. . DNA and Cell Biology . January 1991 . 10 . 1 . 1–14 . 10.1089/dna.1991.10.1 . 1991046.
  3. Mnguni . FC . Padayachee . T . Chen . W . Gront . D . Yu . JH . Nelson . DR . Syed . K . More P450s Are Involved in Secondary Metabolite Biosynthesis in Streptomyces Compared to Bacillus, Cyanobacteria, and Mycobacterium. . International Journal of Molecular Sciences . 7 July 2020 . 21 . 13 . 4814 . 10.3390/ijms21134814 . 32646068. 7369989 . free .
  4. Weber . JM . Leung . JO . Swanson . SJ . Idler . KB . McAlpine . JB . An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea. . Science . 5 April 1991 . 252 . 5002 . 114–7 . 10.1126/science.2011746 . 2011746. 1991Sci...252..114W .
  5. Kim . V . Lim . YR . Lee . I . Lee . JH . Han . S . Pham . TV . Kim . H . Lee . R . Kang . LW . Kim . D . Structural insights into CYP107G1 from rapamycin-producing Streptomyces rapamycinicus. . Archives of Biochemistry and Biophysics . 15 October 2020 . 692 . 108544 . 10.1016/j.abb.2020.108544 . 32822639. 221236896 .
  6. Nzuza . N . Padayachee . T . Syed . PR . Kryś . JD . Chen . W . Gront . D . Nelson . DR . Syed . K . Ancient Bacterial Class Alphaproteobacteria Cytochrome P450 Monooxygenases Can Be Found in Other Bacterial Species. . International Journal of Molecular Sciences . 2021-05-24 . 22 . 11 . 5542 . 10.3390/ijms22115542 . 34073951. 8197338 . free .

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