CYFIP1 explained

Cytoplasmic FMR1-interacting protein 1 is a protein that in humans is encoded by the CYFIP1 gene.^{[1] [2]}

Interactions

CYFIP1 has been shown to interact with FMR1,^[1] to the exclusion of FXR1 and FXR2. It also forms part of the WAVE regulatory complex (WRC),^[3] and based on the crystal structure of the WRC it is believed CYFIP1 provides the binding site for the complex to Rac1.^[4]

Further reading

• Nomura N, Nagase T, Miyajima N . Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. . DNA Res. . 1 . 5 . 223–9 . 1995 . 7584044 . 10.1093/dnares/1.5.223 . etal. free .
• Kobayashi K, Kuroda S, Fukata M . p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. . J. Biol. Chem. . 273 . 1 . 291–5 . 1998 . 9417078 . 10.1074/jbc.273.1.291 . etal. free .
• Witke W, Podtelejnikov AV, Di Nardo A . In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. . EMBO J. . 17 . 4 . 967–76 . 1998 . 9463375 . 10.1093/emboj/17.4.967 . 1170446 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Chai JH, Locke DP, Greally JM . Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. . Am. J. Hum. Genet. . 73 . 4 . 898–925 . 2003 . 14508708 . 10.1086/378816 . 1180611 . etal.
• Brajenovic M, Joberty G, Küster B . Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. . J. Biol. Chem. . 279 . 13 . 12804–11 . 2004 . 14676191 . 10.1074/jbc.M312171200 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Innocenti M, Zucconi A, Disanza A . Abi1 is essential for the formation and activation of a WAVE2 signalling complex. . Nat. Cell Biol. . 6 . 4 . 319–27 . 2004 . 15048123 . 10.1038/ncb1105 . 22767022 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Kawano Y, Yoshimura T, Tsuboi D . CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. . Mol. Cell. Biol. . 25 . 22 . 9920–35 . 2005 . 16260607 . 10.1128/MCB.25.22.9920-9935.2005 . 1280248 . etal.
• Bittel DC, Kibiryeva N, Butler MG . Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome. . Pediatrics . 118 . 4 . e1276–83 . 2006 . 16982806 . 10.1542/peds.2006-0424 . 5453799 .
• Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK . Structure and control of the actin regulatory WAVE complex. Nature . 468. 7323 . 533–8 . 25 Nov 2010 . 21107423. 3085272 . 10.1038/nature09623 . 2010Natur.468..533C.
• Koronakis V, Hume PJ, Humphreys D, Liu T, Hørning O, Jensen ON, McGhie EJ . WAVE regulatory complex activation by cooperating GTPases Arf and Rac1. Proc Natl Acad Sci U S A . 108. 35 . 14449–54 . 30 Aug 2011 . 21844371 . 3167530 . 10.1073/pnas.1107666108 . 2011PNAS..10814449K. free.

Notes and References

1. Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL . A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P . Proc Natl Acad Sci U S A . 98 . 15 . 8844–9 . Jul 2001 . 11438699 . 37523 . 10.1073/pnas.151231598 . 2001PNAS...98.8844S . free .
2. Web site: Entrez Gene: CYFIP1 cytoplasmic FMR1 interacting protein 1.
3. Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK . Structure and control of the actin regulatory WAVE complex. Nature . 468. 7323 . 533–8 . 25 Nov 2010 . 21107423. 3085272 . 10.1038/nature09623 . 2010Natur.468..533C.
4. Koronakis V, Hume PJ, Humphreys D, Liu T, Hørning O, Jensen ON, McGhie EJ . WAVE regulatory complex activation by cooperating GTPases Arf and Rac1. Proc Natl Acad Sci U S A . 108. 35 . 14449–54 . 30 Aug 2011 . 21844371 . 3167530 . 10.1073/pnas.1107666108 . 2011PNAS..10814449K. free.