CY-208,243 explained

CY-208,243 is a drug which acts as a dopamine agonist selective for the D₁ subtype. Unlike most D₁-selective agonists, it shows efficacy in animal models of Parkinson's disease.^{[1] [2] [3] [4] [5]}

Notes and References

1. Gagnon C, Gomez-Mancilla B, Markstein R, Bédard PJ, Di Paolo T . Effect of adding the D-1 agonist CY 208-243 to chronic bromocriptine treatment of MPTP-monkeys: regional changes of brain dopamine receptors . Progress in Neuro-psychopharmacology & Biological Psychiatry . 19 . 4 . 667–76 . July 1995 . 8588064 . 10.1016/0278-5846(95)00110-h. 26670068 .
2. Beninger RJ, Rolfe NG . Dopamine D1-like receptor agonists impair responding for conditioned reward in rats . Behavioural Pharmacology . 6 . 8 . 785–793 . December 1995 . 11224381 . 10.1097/00008877-199512000-00003. 23656469 .
3. Luquin MR, Guillén J, Legarda I, Cruz Rodriguez M, Del Rio L, Dominguez J, Martínez-Lage JM . Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys . Advances in Neurology . 69 . 239–44 . 1996 . 8615134 .
4. D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G . Dopamine D1 receptor agonists induce penile erections in rats . European Journal of Pharmacology . 460 . 1 . 71–4 . January 2003 . 12535862 . 10.1016/S0014-2999(02)02881-9.
5. Salamone JD, Carlson BB, Rios C, Lentini E, Correa M, Wisniecki A, Betz A . Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243 . Behavioural Brain Research . 156 . 2 . 173–9 . January 2005 . 15582103 . 10.1016/j.bbr.2004.05.019 . 10255277 .