CXXC1 explained

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.^{[1] [2] [3]}

Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression.^[2]

See also

• PHD finger
• CXXC5

Further reading

• Wiemann S . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–435 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . vanc. Weil B . Wellenreuther R . 3 . Gassenhuber . J . Glassl . S . Ansorge . W . Böcher . M . Blöcker . H . Bauersachs . S .
• Simpson JC . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–292 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 . vanc. Wellenreuther R . Poustka A . 3 . Pepperkok . R . Wiemann . S .
• Lee JH, Voo KS, Skalnik DG . Identification and characterization of the DNA binding domain of CpG-binding protein . J. Biol. Chem. . 276 . 48 . 44669–44676 . 2002 . 11572867 . 10.1074/jbc.M107179200 . free .
• Carlone DL, Skalnik DG . CpG binding protein is crucial for early embryonic development . Mol. Cell. Biol. . 21 . 22 . 7601–7606 . 2001 . 11604496 . 10.1128/MCB.21.22.7601-7606.2001 . 99931 .
• Lee JH, Skalnik DG . CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals . J. Biol. Chem. . 277 . 44 . 42259–42267 . 2003 . 12200428 . 10.1074/jbc.M205054200 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Barrios-Rodiles M . High-throughput mapping of a dynamic signaling network in mammalian cells . Science . 307 . 5715 . 1621–1625 . 2005 . 15761153 . 10.1126/science.1105776 . vanc. Brown KR . Ozdamar B . 3 . Bose . R . Liu . Z . Donovan . RS . Shinjo . F . Liu . Y . Dembowy . J . 2005Sci...307.1621B . 39457788 .
• Lee JH, Skalnik DG . CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex . J. Biol. Chem. . 280 . 50 . 41725–41731 . 2006 . 16253997 . 10.1074/jbc.M508312200 . free .
• Lim J . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–814 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . vanc. Hao T . Shaw C . 3 . Patel . Akash J. . Szabó . Gábor . Rual . Jean-François . Fisk . C. Joseph . Li . Ning . Smolyar . Alex . 13709685 . free .
• Young SR, Skalnik DG . CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line . DNA Cell Biol. . 26 . 2 . 80–90 . 2007 . 17328666 . 10.1089/dna.2006.0535 .

Notes and References

1. Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T . PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis . Biochem Biophys Res Commun . 271 . 2 . 305–310 . Jun 2000 . 10799292 . 10.1006/bbrc.2000.2614 .
2. Voo KS, Carlone DL, Jacobsen BM, Flodin A, Skalnik DG . Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1 . Mol Cell Biol . 20 . 6 . 2108–2121 . Mar 2000 . 10688657 . 110827 . 10.1128/MCB.20.6.2108-2121.2000 .
3. Web site: Entrez Gene: CXXC1 CXXC finger 1 (PHD domain).